Factor V Deficiency
(Also known as Owren’s Disease, Labile Factor Deficiency, Proaccelerin Deficiency or Parahemophilia. Not to be confused with Factor V Leiden, which is a type of Thrombophilia.)
The Factor V deficiency was first described in a Norwegian patient in 1944. The incidence of Factor V deficiency is estimated at 1 per 1 million. Factor V deficiency is usually inherited in an autosomal recessive fashion, which means it affects men and women equally. There are some case reports of a dominant pattern of inheritance in some families.
The role of the factor V protein is to be a catalyst or “accelerator” in the process by which prothrombin is converted to thrombin.