There are ten clotting factors that are necessary in forming a blood clot. Deficiencies in Factors VIII and IX are well known to most people, but there are other deficiencies that are unfamiliar to most because they are diagnosed so rarely. To date, deficiencies in eight of the lesser-known coagulation factors have been documented in medical literature. Many of these disorders were only discovered or described within the last 40 years.
In most cases, rare factor deficiencies are not genetically sex-linked. They occur in equal frequency among men and women. Often the gene is passed down in an autosomal recessive fashion. This means that when the factor deficiency is inherited from only one parent, the child will be a carrier of the condition, but usually not have symptoms. It is possible for people to inherit a gene from both parents, but this happens very rarely and usually means a more severe manifestation of the disease.
These are the types of rare bleeding disorders that our team treats: