Factor VII Deficiency
(Also known as Alexander’s Disease, Stable Factor Deficiency, or Proconvertin Deficiency. Not to be confused with acquired Factor VII Deficiency, which is associated with liver disease.)
Factor VII deficiency was first recognized in 1951, and originally named Serum Prothrombin Version Accerlerator (SPCA) deficiency. Although the published incidence of Factor VII deficiency is estimated at 1 in 500,000, the disorder may be more common. It is inherited in an autosomal recessive fashion, which means it affects men and women equally.
The Factor VII protein is part of the cascade of clotting factors that form the chain leading to a protective blood clot. Factor VII deficiency is usually severe. In fact, patients with less than 1% Factor VII activity experience similar symptoms to hemophilia.